A good camera backpack is a given. I did some spreadsheet calculations based on what you wrote above and the weights given on the manufacturers pages and, good for you, but that would total up, including the necessary other accessories (batteries, filters, flash, gps, etc.) to at least 15 1/2 pounds dead weight (which is actually the limit for carryon roll-aboards for international flights, btw!)
plus of course what one carries around during the day (jacket? hat? water bottle? first aid kit? snacks? etc....)
No matter how "comfortable" anyone claims their backpack is, carrying 15 -16 pounds
plus plus around on your back all day, walking around town, standing in line, standing in museums, hiking up hills (let along mountain trails), trying to get in an out of transportation, walking, standing, walking, standing, etc., all day, every day for weeks on end and find it perfectly carefree, comfortable and not a burden, well, good for those people. Personally, I can't think of anyone I know that would find that a comfortable, strain-free way to travel. (Did a mini-survey during Christmas visits, btw. ) So, what really matters is not the backpack, but if you have a porter to carry your bags for you. (I did that in Nepal and India many years ago. Worked great, and after two months of traveling like that, my back was just fine!)
And given the huge size of a backpack required for all that equipment to carry around all day, well, "blending in" or at least not standing out as a gringo with $20,000 worth of stuff on their back will be difficult, especially when you stop to open up your camera store on the pavement someplace for all to see... In remote / primitive areas, one would need to carry a lot
more "stuff" (like water, food, medical supplies, etc. etc.) so that pack becomes much heavier upwards of 22 -25 pounds at that point easy, and space at a premium as a result. (Grand Canyon hike is a great example. Every lens could be a bottle of water or food... And as the saying goes, "ounces add up to pounds and pounds add up to exhaustion"...) And in Japan/Korea for example, a backpack that size just won't fit in most places (esp. public transportation.)
So, my hat's off to those who pack the the camera kitchen sink, but I just can't see where it would work for very long... without porters, that is.